Agreed. And so does my wife. LCR in 22lr for her. I gave her numerous opportunities at higher calibers in both revolver and semi auto. She made her choice and I am good with it because she is carrying the largest caliber she is comfortable with and she does shoot it very well.I recommend carrying the largest caliber you can comfortably carry AND shoot well. If 22LR is that caliber, then that is what you should carry.
The Mossad used the .22lr very effectively also. Mafia hit men and assassins cooly whacking their targets are a far cry from an armed citizen defending themselves in an unexpected situation. Use what you want/ have available/ can handle. The best tool for the job will likely have a bore between 0.35" and 0.45" in diameter.Mafia used 22's for decades and still do.
Personally I think they have their place for SD as does any weapon
A centermass doubletap hit with a 45 ACP will be a lot more discouraging to a meth head than a 22 with the same hits.Two people have mentioned adrenaline and drug effects making someone not stop with a .22. The reality is that those scenarios apply with a .45 as well. I've said it many times and I'll say it again; presentation stops most threats; bright flash/loud bang stops most that go beyond that whether you hit the assailant or not. Pain from a wound is minimally different, though transfer of energy is. A .22 with proper shot placement is a kill. A .45 with poor shot placement may be just as ineffective as a .22 with a hit in the same area. Pain will cause shock (outside of the adrenaline/drug argument) in either case.
NOW, I carry a 9mm or a .45ACP, but if .22LR was all I had available, I would carry that. I recommend carrying the largest caliber you can comfortably carry AND shoot well. If 22LR is that caliber, then that is what you should carry.