My favorite 45 Colt load is 18 grains 2400 with 250 grain coated flat point with Federal large pistol primer. It’s around 1100 FPS from my 4 5/8” Blackhawk and very accurate.
I didn't find any ruger only loads for cfe pistol just did a ladder up .5 grains at a time till it flattened the primer a bit cases fell out and some soot. I did do a lilgun ruger only load from hogdon book worked up to a maxload of 27.5 WOW what a boomer I backed off to 26.5 minimum load which was listed as min still stout but ok 👍 thanks for all your posts about 45 colt lots of good info to use and I don't load cfe like that any more I just tried them I'll stick to book data those lil gun and 225 ftx loads are in the book and they will work on any game I'll go after now to see how I'll load my 255 lee cast after I look up my hardness. In my new vaquero 7 gr reddot got me a nice 300 lb black bear so I know it will perform well as long as I follow hardness vs pressure.No opinion as I only tested >= 250gr lead bullets. As long as the CFE Pistol load is listed in the reloading manuals you should be fine. Hopefully that is where you got the load (I didn't check).