The Alaskan in .454 Casull/.45 Colt...will handle the .45 Colt (or sometimes known as the Long Colt), which is actually very comfortable to shoot in the 2.5" barreled revolver! The .454 Casull, which is really the 'magnum' version of the .45 Colt, is a bit more powerful and takes a little getting used to, especially if someone has a hesitancy about shooting it! I, however, prefer the heavier calibers...and find them fun to shoot (but not very many rounds at a time.)I've never shot an Alaskan, mainly because something that big with just a 2.5" barrel frightens me a little. I would would love it, if only it had a 4 or 5" instead. (please no "that's what she said" comments) What's the next best thing?