Lister, It truly depends on how tight your revolver's throats are. If the throats are under .4515" for a 45 cal or are oval (both are quite common) then yes indeed, it will affect accuracy with jacketed bullets. After the throats are reamed to .4525", it optimizes the gun for lead bullets but accuracy with jacketed bullets will be just fine. Larger throats will loose a little pressure with jacketed bullets so muzzle velocity will typically drop about 25 fps ... not a bad trade for better accuracy. The same data holds true for a 44 cal only the throat diameters should be .4305" and for a 357 cal, .3585" diameter throats. Most high quality bullet manufacturers have settled on precise .451" jacketed bullet diameter for 45 cal, .429" diameter for 44 cal, and .357" diameter for 38/357 cal. Lead bullets should be at least .452" for 45 cal, .430" for 44 cal, and .358" for 38/357 cal. There can be huge variations in lead bullets ... in fact the ones I use in my 45 are swaged and made by Hornady. They are .454" diameter but shoot exceptionally well in several of my revolvers reamed to .4525".
Here's what you can do to test your revolver. Remove the cylinder from the gun and make sure it is clean. Try to insert high quality .451" jacketed bullets .... nose first into the front of the throats. You should be able to push the bullet through the throat with slight finger pressure. If the bullet won't pass through all the throats, you will need to ream them to get decent accuracy with jacketed bullets. Test all six because Ruger uses a "gang" reamer at the factory to power ream all 6 at once. That means some holes may be perfect while others are either too tight, too loose, or oval. Repeat the same test with a high quality .452" lead bullet. This time use a separate bullet for each throat because the throat will resize the bullet and give false indications. In a lead bullet optimized gun, the .452" bullets should pass through the throats with light finger pressure. If your throats have not been reamed, I can almost guarantee you the bullets won't pass through the throats without a hammer.
Here's the concept for bullets and revolvers ... Unlike semi-autos where the bullet just transitions direct from the case to the bore, revolvers have a few more problems to resolve. First is cylinder-to-bore alignment. There's no such thing as perfect C-T-B alignment and with Rugers, "close" is about the best you can expect. Not to worry ... Ruger does some nifty engineering to compensate. Ruger designs their revolvers with a little cylinder play. The cylinder latch allows several thousandths of + and - side play while the base pin is a bit loose and allows a couple thousandths of vertical play. When a round is fired, this play allows the cylinder to move a tiny bit to self align with the bore as the ogive of the bullet enters the forcing cone. Assuming there is enough play, the bullet will enter the forcing cone with minimal distortion (shaving). Side note: next time you check a Ruger SA for cylinder play, don't bitch if it isn't mouse ear tight. Also, replacing the base pin with a custom pin can raise the cylinder where it will shave bullets. Leave the factory base pin in the gun ... it's part of the nifty design.
Mean time, when a round is fired, the bullet begins to exit the case and starts into the throat under considerable pressure. Chamber pressure forces the bullet to take the shape of the throat. If the throat is too tight it acts like a die and sizes the bullet down in diameter. If the throat is slightly larger that the bore (highly desirable), chamber pressure will cause the base of the bullet to expand until it is the same diameter as the throat (.4525" in a 45 cal).
If C-T-B alignment were perfect, you wouldn't need a forcing cone. As stated above, that ain't gonna happen with a Ruger so the factory cuts an 8 degree forcing cone to provide a transition from the cylinder to the bore. So what we should have is a bullet that is slightly larger in diameter than the bore being pushed by a huge amount of pressure (7 tons in a 45 Colt, 18 tons in a 44 Mag). This forces the bullet to seat in the bore very tight and forms a really good pressure seal. If the bullet remains sealed in the bore until it exits, accuracy will be optimum and lead fouling will be minimal. Oddly enough, material from an oversized bullet will be reshaped not shaved off. High pressure does weird things.
Here's what happens if things aren't what they are supposed to be ... If the throat is too tight, the bullet will get sized down smaller than bore diameter. This has the same effect as shooting smaller diameter bullets. It becomes impossible for the bullet to seal in the bore so hot gasses blow by the bullet. This vaporizes the circumference of the bullet and leaves lead residue behind. Pressure lost to blow-by will reduce the muzzle velocity considerably. As more rounds are fired, lead fouling continues to build up which distorts the bullets and causes accuracy problems. Bottom line ... poor accuracy and too much fouling. If the forcing cone has machine marks or other corruption (very likely in a Ruger), using an 11 degree reamer will provide a smooth transition from mouth to bore and be a bit more forgiving if C-T-B alignment is off.
I highly recommend doing the cylinder throat chamfering and the 11 deg forcing cone. Between the two, that old Ruger will shoot some mighty fine groups with minimal fouling. Sorry for the "book" ... hope it helped.