The LCR was made to be a very light all day carry defensive gun. I hear they are durable, but revolver fans (like me) will still favor an all-steel gun like the GP100 for actual shooting.
Revolver fans tend to be very traditionalist and don't like change...in a world of hi-cap polymer frame pistols, wheelgun nuts like things to stay the way they are. With as many S&W fans who threw a fit about the locks on the revolvers and MIM parts, I don't see a big poly revolver being well accepted at all.
.....and many of the people who love poly frame auto pistols could care less about anything with a cylinder. The two don't tend to mix, most revolver fans won't buy a poly frame GP100-sized revolver. There's a reason the SP101 is still very popular, it's Rugers mainstay compact all-steel revolver and the LCR will never fully replace it.
The only thing I could see being less accepted than a full size poly frame DA revolver is a poly frame Single Action wheelgun

A few people would buy them just to have something different, but not many would sell overall.