Excellent summation of the comments on this web about the 345. I agree 100%.cmann ... My P345 is nearing the 4,000 round mark and other than 2 fail to feeds during the 1st 50 rounds, it has been perfect. My thoughts are as follows:
1. Ergonomics - It feels like it was made for my hand and is well balanced IMO.
2. Size / Weight - At 5.75" height, 7.5" length and 29oz, while not a compact, it conceals relatively easily when I carry it upon occasion (CB Supertuck IWB or Hume JIT Slide OWB)
3. Sights - Adequate (Stock front and rear sights are windage adjustable).
4. Accuracy - While not a target pistol by any stretch of the imagination, at combat distance (up to 30') it will easily hold 5 shot groups of 2" or less.
5. Trigger - Typical P series with quite a bit of travel (the hammer spring can be lightened a bit to improve the trigger pull).
6. Durability - It has shown no signs of unusual wear (including the rails)
7. Ammo sensitivity - No issue as it has digested a wide variety of FMJ & JHPs
You will likely find (as you continue your research) that some folks have apprehension regarding the P345 concerning it's initial "click-no-bang" problem. The C-N-B was brought about by dry firing without the magazine in place, which caused the firing pin to damage the magazine disconnect plunger to the point that the firing pin couldn't get past the disconnect plunger (thus click-no-bang). Between Ruger's design change to the slide (providing additional clearance between the plunger and firing pin) and the warning that they added the manual (not to dryfire without the magazine in place), IMHO it's really a non-issue at this point.
Hope that it helps ... Good luck on your decision!