Which powder depends on what you are using it for . My one powder is Red Dot for all my .357/.38 loads ... but it isn't a high velocity load. I'd move up to 2400 for that if needing a bit of velocity. Never have used H110.... There just isn't 'one' great powder for all uses! Just like for hunting the big animals there is the .4x calibers and for rabbits you have .22 up to the peanut .357.... Not one fits all....if you could have one powder to load for .357 what would it be?