Excellent!! explanationThe 357 New Vaquero is the same medium frame (other than fixed sights) that Ruger started with back in '55. If will handle anything you throw at it. You will have NO, NONE, NOTTA worry about shooting .357 hot, medium, mild in it. Just because the CAS crowd uses powder puff loads ... doesn't mean the gun is weak!
As for .45 Colt, the New Vaquero will handle what Brian Pearce calls Tier 2 loads (20,000psi). Just can't shoot Tier 3 which is Ruger Only Loads (30,000psi).... Again not a 'weak' revolver. Tier 1 is standard SAAMI loads (14,000psi) for those 'old', 'old' revolvers still out there. No worry! Brian Pearce .45 Colt PDF
A clinger. I do like Single Actions.... .45 Colt (Sometimes improperly referred to by its alias as the .45 'Long' Colt or .45LC) is THE caliber of choice. You can't go wrong with a .44Special either.