High grade barrels like Lilja, Hart, PacNor, and McGowen are a joy to use. The .204 Ruger is a one of the very best small varmint rounds especially for small rodents like prairie dogs and gophers. It will also anchor larger rodents like rock chucks and their eastern clan the wood chuck, with authority up to almost 400 yards. It closely duplicates 50 grain .22-.250 trajectories up to 400 yards with 40 grain bullets
My .204 Ruger, a Ruger Hawkeye, has a 22 inch McGowen barrel, 1-11 twist and I have been shooting 40 grain VMax bullets with IMR 8208 powder. In the works is another .204 Ruger, this one will have a heavier 24 inch #4 contour barrel, also with a 1-11 twist. The objectives are to reduce muzzle jump enabling hit spotting and higher velocities. Barrel life is excellent, cheap to shoot with 26 or so grains of powder. The 1-11 twist stabilizes the 40 grain boat tail plastic tip Vmax.
Upon performing the re-barrel job the gun smith will lap the bolt lugs so both lugs contact the inside of the receiver and square up the front of the receiver ring. Be sure to ask him to do this. The MKII uses a simple barrel/receiver arrangement much like a M98 Mauser and the re-barrel job is simple.
These high grade barrels are usually extensively lapped and extremely smooth inside and resist fouling. Going to a powder like .223 CFE and the newer IMR 4166 should help when shooting lots of rodents like prairie dogs. The new IMR 4166 might be a better choice when the temperature gets up to 90 degrees.
Shooting lots of hand size rodents at ranges over 300 yards is sort of a challenge. Having a really high quality barrel on a high quality rifle with a good trigger, good scope that holds a zero and minimizes eye strain, and ammo of the best kind will markedly increase your shot to shot kill probability. Don't let it get too hot and clean it say every 100 or so rounds.
For me there is no debate to go for a re-barrel job with a barrel like I have talked about. I can spend 500 bucks or so at the neighborhood plant nursery only to have the deer chew the little plants down to bare twigs. Instead my .204 Ruger is ready to go in the gun safe with some 500 or so loaded rounds of ammo.