I've seen it done.
I don't remember which member posted pics on how to do it, but they installed some speed six grips on the gun and outlined the shape on the grip frame and then ground off the excess.
Maybe that member will chime in with their pictures?
I need the higher visibility adjustable sights for eyes that are getting older otherwise just going with a Speed Six would be a great solution (I carried a Speed Six when I worked the streets back in the late 70's).
Security Sixes do not have much collector value, they seem to be gobbled up by folks wanting them asshooters.
I round butted my stainless Security-Six over twenty years ago. It usually wears pac compact grips. Even with the round butt all of the other grips I have will still fit just fine but the pac grips give such big improvement in feel that it is impossible to describe. You really have to fire full house mag loads to notice the improvement.