I love the 10/22, but my favorite rifle would be a 77 MK 2 in 30/06 I have. It has a Timney trigger, a Hougue stock, a ER Shaw bull barrel, lapped lugs, and has been glass bedded. It is a tack driver! Also fond of the Mini 14, although they could benefit from a bigger barrel.
I had a model 77 30/06 with a variable 6/18 scope that I could bust the small beer bottles at 200 yards with and traded it off. That was a mistake and I haven't got one since. Would like to have a stainless one.
I have threeof them and it depends on what I am doing with it. For general plinking I like the Bushmaster AR-15 heavy barrel. If at the range and shooting long distance it would be my Savge 26" fluted heavy barreled 308. In time of selfdefense or hurricane I trust my AK-47. For hunting it would have to be my 30-30.
I would be hard pressed to pick my all time favorite rifle, I've got many and like them all! But when push comes to shove, I guess my favorite rifles would be my M1 Garands. Yes, I know there are others that are more accurate and are lighter and shoot a faster cartridge,....the list goes on,....but the Garand has to be my favorite.