I CC in an OWB holster daily and, sometimes (at least for quick runs out to the grocery store, etc.) I'll throw a 5-shot .38 in a vest or coat pocket...but I have a bulldog nylon holster I put it in a) to protect it, b) to block access to the trigger so as not to have a negligent discharge, and c) to avoid 'printing'.
While in Pocket Carry mode, it's not 'quick' per say...but I do have one with me and I do practice knowing what's going on around me, constantly, so as not to have someone come up behind me nor to be surprised by someone or something simply because I wasn't paying attention...giving me more time to assess, consider options, and respond if needed.
Situational Awareness and Distance are two of the greatest defenses out there...use them as needed...when needed...and first, if possible!