How far will you be shooting and at what size of target? What types of reticles and with which methods of trajectory management are you comfortable, or which do you prefer?
Personally, I zeroed mine at 100, and have a milling reticle and exposed turrets to allow for compensation of the rather arched short range trajectory of the .350L. But I have never been one to use a large MPBR standard, and I do expect the round to deliver at 300-400 yards on occasion. When I play MPBR games, I still zero at 100, but then dial a bit to get to the 175-250yrd zero equivalent for the cartridge’s MPBR.
If you’re shooting 150 and less, still zero at 100.