The 300 Blackout cartridge is unique and resembles a 30 Carbine more than it does common bottle neck rifle cartridges. As such, it uses the same slow burning powders as a 30 Carb or magnum handgun cartridges such as a 327 Fed Mag, 357 Mag, 41 Mag, 44 Mag or even 410 shotguns.
In the overall scheme of powder burn rates, there are fast burners for light target handgun loads, then there are medium burn rates for mid-velocity handgun loads. Slow burning magnum powders for handguns are at the beginning edge of fast burning powders for rifles. The 300 BO falls in the unique "magnum handgun" category .... not slow enough burning to be called a rifle powder and not fast enough burning to be called a normal handgun powder. The powders that produce the highest velocity in a 300 BO without exceeding the max chamber pressures are the slowest burners like Accurate 1680. The fastest burners like AA #9 develop the slowest velocities with the highest chamber pressure. The traditional Magnum handgun powders are the most versatile. These include Alliant 2400, Lil'Gun, Win-296, H-110, and IMR 4227.
I have been using W-296 for decades and have found it to be very predictable, accurate, and universal for all magnum handgun cartridges so I would buy it for 300 BO without hesitation. It works for all listed 30 cal bullet weights from 110gr to 225gr.
When using any of the slow burning powders, filling the case to at least 75% is essential to prevent squibs. Assuming a 150gr bullet, the 75% risk area would be 12gr or less of W-296 in the 300 BO, which uses from 12.7 to 16gr of W-296 so it will never fall into the risk area for squib loads. W-296 will maintain enough barrel pressure for gas operated actions, so it should meet all the criteria for a 300 BO and virtually all Magnum handgun loads from a 327 Fed Mag to a 45 Colt Ruger Only. It's also a great 410 shotgun powder.