I used to live in Lamar, CO where I went prairie doggin' a couple times a month. It was very common for my shooting buddy and I to log a couple hundred kills per trip. I used a Rem 700 BDL, chambered in 223 Rem for long shots, a Winchester Mod 9422M for 75~100 yard shots, and my Remington Mod 511, bolt action 22 LR rifles for shots under 75 yards. Most of the kills were made with 22 LRs. We would drive my old '71 El Camino in the prairie dog town and set up a shooting bench. Surprisingly, prairie dogs were curious and kept an eye on us, barking from one of their mounds. For long range shots, PDs were out in the open, grazing on vegetation. For closer shots, about all you get is a quarter coin sized head shot so you need a good accurate rifle. It was great fun and we did the ranchers a big favor by keeping the prairie dog population under control.
I don't think I ever visited a prairie dog town without seeing rattle snakes. They liked to get in abandoned PD holes, burrow owls too. I only had to shoot one rattler ..... it crawled under my shooting bench and coiled up about 18" from my leg. My Single-Six came in handy that day.